中国抗癌药物的价格谈判和定价:一项观察性研究
Jing Zhou1,2, Tianjiao Lan1,2, Hao Lu3
1HEOA Group, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
PLoS medicine
|January 2, 2024
概括
自2017年以来,中国每年的药物价格谈判改善了抗癌药物价格与临床价值的调整. 这一政策导致了显著的成本削减,并减少了给定临床益处的价格波动.
科学领域:
- 卫生经济学 卫生经济学
- 制药政策 制药政策
- 在瘤学瘤学.
背景情况:
- 中国在2017年实施了与退款相关的年度药品价格谈判,重点是医疗保险的价值定价.
- 这些谈判对将抗癌药物价格与临床价值保持一致的影响仍然不足以确定.
研究的目的:
- 评估中国价格谈判后抗癌药物价格的变化.
- 在谈判后评估药物价格和临床价值之间的关系.
主要方法:
- 从中国国家补偿药物清单 (NRDL) 中,对103种抗癌药物指示进行了观察性研究,这些药物在2017-2022年期间成功谈判.
- 对关键临床试验数据的安全性,生存率,生活质量和整体反应率 (ORR) 的分析.
- 回归分析以检查治疗成本与临床价值之间的关联,在谈判前和谈判后进行.
主要成果:
- 谈判后的中位治疗费用从34,460.72美元大幅降至13,688.79美元 (P < 0.001).
- 谈判前,增加生存率和ORR与更高的成本相关;谈判后,这些关联仍然存在,但给定价值的成本变化减少了.
- 限制包括数据透明度问题,缺少临床价值数据和有限的样本大小.
结论:
- 中国的价格谈判政策导致抗癌药物定价更好地反映了临床价值,即使大幅降低价格.
- 这些发现为其他面临药品支出上升和资源限制的国家的价格监管提供了洞察力.
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