抑郁和焦虑症状是否会影响多发性硬化症步行尺度-12分数的构造有效性?
Petra Šilić1, Catherine D Jones2, Brenda Jeng1
1Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago.
Rehabilitation psychology
|January 2, 2024
概括
多发性硬化症行走量-12 (MSWS-12) 准确地测量了多发性硬化症 (MS) 患者的行走功能障碍,即使是那些患有抑郁和焦虑的人. 这种患者报告的结果 (PRO) 尽管存在这些常见的MS并发症,但仍然有效.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 精神病学是一个精神病学.
背景情况:
- 走路功能障碍,抑郁和焦虑是多发性硬化症 (MS) 的常见和相互关联的问题.
- 多发性硬化症行走量-12 (MSWS-12) 是一种广泛使用的患者报告结果 (PRO) 用于评估MS患者的行走功能障碍.
- 抑郁和焦虑症状对MSWS-12得分的构造有效性的潜在影响需要调查.
研究的目的:
- 确定抑郁和焦虑症状是否会影响MSWS-12得分在患有多发性硬化症的人群中的构造有效性.
- 评估MSWS-12的可靠性,以此来衡量在存在心理伴随性疾病时的行走功能障碍.
主要方法:
- 189名患有MS的参与者完成了MSWS-12,医院焦虑和抑郁量表 (HADS-D和HADS-A),6分钟步行 (6MW) 和定时25英尺步行 (T25FW).
- 进行了两变相关性分析,以检查MSWS-12得分与步行测量之间的关联,对HADS-D和HADS-A得分进行控制.
主要成果:
- MSWS-12得分与6MW (r = -0.752) 和T25FW (r = 0.694) 有显著的相关性.
- 控制抑郁和焦虑症状并没有显著改变MSWS-12和步行测量之间的相关性 (pr = -0.725为6MW,pr = 0.685为T25FW).
- 在MSWS-12和步行测量之间存在强烈的相关性,即使在具有高抑郁和焦虑分数的子样本中也是如此.
结论:
- 这些发现支持MSWS-12得分的构造有效性,作为MSMS中行走功能障碍的可靠PRO.
- 该MSWS-12是有效的步行功能障碍的测量,即使在MS患者经历抑郁和焦虑症状.
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