新兴的纳米材料的合成和生物应用
David Skrodzki1, Matthew Molinaro2, Richard Brown3
1Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
ACS nano
|January 3, 2024
概括
基于哈夫尼的纳米粒子由于其高原子数,增强辐射效应并使X射线对比,对癌症治疗和成像有很大的希望. 研究重点是合成和应用,以改善临床翻译.
科学领域:
- 纳米技术和材料科学 材料科学
- 生物医学工程 生物医学工程
- 放射化学 放射化学是指辐射化学.
背景情况:
- 工程纳米粒子在纳米技术中至关重要,金属纳米粒子已被广泛研究用于生物医学用途.
- 它们的惰性性质,纳米尺寸和可调节性质使得它们非常适合用于药物输送,传感和治疗等应用.
- 基于海的纳米材料,特别是氧化海,由于它们的高原子数 (Z=72) 提供了独特的优势.
研究的目的:
- 对基于的纳米材料的合成方法进行审查.
- 总结它们在治疗,成像和生物传感方面的应用.
- 讨论临床进展和未来纳米医学翻译的挑战.
主要方法:
- 对纳米材料的合成策略的文献综述.
- 对影响生物医学应用的物理化学性质的分析.
- 检查放射敏感化和成像中的机械原理.
主要成果:
- 哈夫尼的高Z和质衰减系数提高了放射治疗的疗效和X射线成像对比度.
- 氧化纳米粒子具有生物相容性和可调节的光学/电子特性.
- NBTXR3证明了高Z辐射敏感化纳米材料的临床潜力.
结论:
- 基于的纳米材料为先进的癌症治疗和诊断提供了多功能功能.
- 优化合成和理解属性-应用关系是临床翻译的关键.
- 需要进一步的研究来应对当前的挑战,并加快纳米医学的发展.
相关概念视频
Microbial Corrosion
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
iChip
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Microbial Biosensors
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...


