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CD147通过驱动M1表型和损害细胞形成,引发动脉样硬化

Jian-Jun Lv¹, Hao Wang¹, Cong Zhang¹

¹Department of Cell Biology, National Translational Science Center for Molecular Medicine (J.-J.L., H.W., C.Z., T.-J.Z., H.-L.W., Z.-K.L., Y.-H.M., Q.H., L.-J.W., Z.-N.C., H.B.), Fourth Military Medical University, Xi'an, China.

Circulation research

|January 3, 2024

概括

骨髓体CD147 (分化147集群) 通过促进炎症和抑制血细胞增生,驱动动动脉硬化. 用抗体向CD147为动脉样硬化疾病提供了一种新的治疗策略.

科学领域:

免疫学免疫学免疫学
心血管生物学心血管生物学
分子医学是分子医学.

背景情况:

动脉样硬化是一种主要的全球健康挑战,其特点是慢性炎症和斑块发育.
巨细胞在动脉样硬化病变的发病过程中发挥着中心作用.

研究的目的:

为了研究神经样衍生的CD147 (分化集群147) 在动脉样硬化中的作用.
探索针对CD147进行治疗干预的翻译意义.

主要方法:

在apoE缺陷背景下生成骨髓细胞特异性CD147淘汰和过度表达的小鼠模型.
分析了巨细胞的两极分化,炎症媒介的产生 (NO, iNOS) 和细胞分裂.
研究了TRAF6-IKK-IRF5信号通路.
使用了人性化的CD147转基因小鼠模型,并测试了对抗人类CD147抗体的有效性.

主要成果:

骨髓细胞CD147缺乏改善了动脉样硬化和炎症,将巨细胞转移到抗炎性表型.
通过TRAF6-IKK-IRF5通路,CD147促进炎症,并通过抑制GAS6.6来抑制乙细胞分裂.
抗人类CD147抗体治疗通过向炎症和血细胞分裂,在人性化的小鼠模型中抑制了动脉样硬化.

结论:

骨髓细胞CD147是动脉样硬化斑块进展的关键驱动因素.
用抗体向CD147代表了对动脉样硬化疾病的有前途的补充疗法.

关键词:

动脉样硬化动脉样硬化这种细胞的形成是Efferocytosis.这是一种炎症炎症炎症炎症.巨细胞是什么?巨细胞是什么?鼠标鼠标鼠标鼠标

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