在双胞胎怀孕期间推的血清脂基值,并评估其与围产期结果的关联
Jiaqi Huang1, Xinlu Meng1, Jiaxin Li1
1Peking University Third Hospital, Beijing, China.
BMC pregnancy and childbirth
|January 3, 2024
概括
这项研究确定了双胞胎怀孕的关键血清脂质参考范围. 识别异常的脂质水平可以帮助预测妊娠不良结果,如妊娠期糖尿病和高血压.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 临床生物化学 临床生物化学
背景情况:
- 怀孕期间母亲的脂质代谢变化与不良结果有关.
- 缺乏专门针对双胞胎怀孕的确定的正常脂质值.
- 这项研究旨在确定双胞胎妊娠的血清脂基准范围.
研究的目的:
- 为双胞胎怀孕建立血清脂质参考范围.
- 为了确定总胆固醇,甘油三,HDL-C和LDL-C的正常范围.
- 提供一种工具,用于识别双胞胎怀孕中不利的脂质样本.
主要方法:
- 从2011年至2021年间,对881例双胞胎怀孕的回顾性分析.
- 在怀孕早期和中期,对脂质水平 (TC,TG,HDL-C,LDL-C) 的描述性分析.
- 排除具有不良结果的怀孕,以确定参考范围.
主要成果:
- 血清脂质水平 (TC,TG,LDL-C,HDL-C) 从怀孕早期到晚期显著增加,其中TG显示出最大的上升.
- 推的参考范围:怀孕早期 (Tc <5.31,Tg <2.25,HDL >1.02,LDL <3.27 mmol/L);怀孕中期 (Tc <8.74,Tg <4.89,HDL >1.25,LDL <5.49 mmol/L). 怀孕中期 (Tc <8.74,Tg <4.89,HDL >1.25,LDL <5.49 mmol/L) 怀孕中期 (Tc <8.74,Tg <4.89,HDL >1.25,LDL <5.49 mmol/L) 怀孕中期 (Tc <5.31,Tg <2.25,HDL >1.25 mmol/L) 怀孕中期 (Tc <8.74,Tg <4.89,HDL >1.25,LDL <5.49 mmol/L) 怀孕中期
- 较高的脂质水平与妊娠糖尿病,妊娠引起的高血压有关,并且对于妊娠年龄来说很小.
结论:
- 在中国双胞胎怀孕人口中,血脂的确立参考范围.
- 这些范围可以帮助识别具有不利脂质谱的双胞胎怀孕.
- 增加的孕产妇脂质水平与增加妊娠不良结果的风险有关.
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