艾滋病毒感染者的体重减轻和死亡率:系统性审查和元分析
Sarah Almeida Cordeiro1, Tainá Costa Pereira Lopes2, Antonio Luiz Boechat2
1Program in Health Sciences (PPGCIS), Faculty of Medicine, Federal University of Amazonas - UFAM, Afonso Pena Street, 1053, Centro, Manaus, Amazonas, Brazil. sarahalmeidacordeiro@gmail.com.
BMC infectious diseases
|January 3, 2024
概括
接受高活性抗逆转录病毒疗法 (HAART) 的艾滋病毒感染者 (PLHIV) 减肥显著增加死亡风险. 这项系统性审查发现,在体重减轻的住院PLHIV患者中,死亡风险高1.5倍.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 从历史上看,体重减轻是早期人类免疫缺陷病毒 (HIV) 病例中死亡率的预测因素.
- 高活性抗逆转录病毒疗法 (HAART) 改善了许多艾滋病毒感染者 (PLHIV) 的体重结果.
- 然而,一些接受HAART的PLHIV患者继续经历无意减肥.
研究的目的:
- 为了确定在HAART治疗中体重减轻的住院PLHIV是否与没有体重减轻的人相比,死亡率更高.
- 为了研究在接受HAART的住院PLHIV患者中减肥和死亡率之间的关联.
主要方法:
- 对前性队列研究进行了系统审查和元分析.
- 通过MedLine,Embase和LILACS数据库确定了研究,这些数据库于2020年3月至2023年10月之间发表.
- 风险比率 (RR) 和随机效应模型被用于分析死亡风险,其质量由乔安娜·布里格斯研究所和GRADE系统评估.
主要成果:
- 包含了10项涉及1637个PLHIV的研究,数据涵盖1996年至2017年.
- 住院PLHIV患者在HAART治疗中减肥后死亡的发生率为57.5%.
- 与没有体重减轻的PLHIV相比,体重减轻与死亡风险增加1.5倍 (RR:1.50,95% CI:1.03,2.19,p=0.04).
结论:
- 体重减轻是接受HAART的住院PLHIV患者死亡的一个重要风险因素.
- 尽管有HAART,但由于死亡风险增加,这一群体的体重减轻需要密切监测.
- 这一结论的信心水平非常低,表明需要进一步研究.
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