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在患有莫亚莫亚病的儿童和成年人中扩大周周血管空间和狭闭性变化

Min-Gyu Park¹, Jieun Roh², Sung-Ho Ahn³

¹Department of Neurology, Pusan National University Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University School of Medicine, 20 Geumo-ro, Yangsan, 50612, Republic of Korea. umbilicus2@gmail.com.

|January 3, 2024

概括

在莫亚莫亚病 (MMD) 中,扩大周血管空间 (DPVS) 主要影响白质,儿童和成人之间没有高等级的差异. 白质DPVS的不对称性与MRA发现相关,表明减少动脉脉动对DPVS的影响.

科学领域:

神经学神经学
放射学放射学是一门学科.
大脑小血管疾病大脑小血管疾病

背景情况:

扩大周血管空间 (DPVS) 是脑小血管疾病的成像标志物.
已知莫亚莫亚病 (MMD) 中DPVS存在,但它们的特定模式和关联仍未得到充分探索.
了解MMD中的DPVS对于表征疾病的成像表型至关重要.

研究的目的:

调查儿童和成人MMD患者DPVS的分布模式.
确定DPVS和MMD特征的狭闭包性变化之间的关系.

主要方法:

使用T2加权成像,DPVS在基底 (BG) 和白质 (WM) 中进行了半定量得分.
DPVS的严重程度分为高 (得分>2) 或低 (得分 ≤2).
使用MR血管造影 (MRA) 来分级静脉封闭性变化;不对称性被定义为半球之间的≥1级差异.

主要成果:

高度WM-DPVS (88.2%) 在51名MMD患者中流行.
BG-DPVS发生在72.5%的患者中,但始终是低度的.
在WM-DPVS中的不对称性与MRA分级不对称性有显著的相关性 (肯德尔的tau-b=0.604,P<0.001).

结论:

在MMD中高度DPVS主要局限于白质,在儿童和成人中分布相似.
不对称的WM-DPVS和MRA等级之间的相关性表明,由于狭性闭塞性疾病导致大脑动脉脉动力减弱会影响WM-DPVS.
这些发现增强了对DPVS作为MMD病理生理学中的潜在成像生物标志物的理解.

关键词:

脑血管疾病脑血管疾病淋巴系统淋巴系统莫亚莫亚病是莫亚莫亚病的一种疾病.周血管空间是周血管空间.

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