在失去唯一孩子的汉族中国成年人中,SLC6A2基因多态和大脑体积之间的关系
Zhuoman Xia1, Zhihong Cao2, Wesley Surento3
1Department of Medical Imaging, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 210002, China.
无论PTSD诊断如何,SLC6A2基因多态性都会影响特定大脑区域的灰质体积. 这种基因型-诊断相互作用在上额回形可能在失去唯一孩子的成年人中发挥PTSD发展的作用.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 由SLC6A2基因编码的北上腺素转运体 (NET) 是理解创伤后应激障碍 (PTSD) 病变的潜在目标.
- 之前的研究还没有探讨SLC6A2基因变异与PTSD患者的神经成像异常之间的联系.
研究的目的:
- 为了调查T-182 C SLC6A2基因型和灰质体积 (GMV) 之间的关联,汉族中国成年人失去了他们唯一的孩子.
- 检查PTSD诊断的影响,SLC6A2基因型,以及它们对GMV的相互作用.
主要方法:
- 磁共振成像 (MRI) 和临床评估对218名参与者 (57名PTSD,161名非PTSD) 进行.
- 参与者被基因型为SLC6A2 T-182 C多态 (TT,CT,CC).
- 一个2x3的因数设计分析了GMV,Pearson的相关性评估了GMV和临床分数 (CAPS,HAMD,HAMA) 之间的关系.
主要成果:
- 在SLC6A2基因型显著影响了在左上顶回 (SPG) 和双边中间带状回 (MCG) 的GMV.
- 在左上额头 (SFG) 中观察到显著的SLC6A2基因型-诊断相互作用.
- 在临床评分和基因型/对转基因病毒相互作用影响之间没有发现显著的相关性.
结论:
- SLC6A2多态度调节SPG和MCG体积,独立于PTSD诊断.
- 在SFG中的SLC6A2基因型-诊断相互作用可能会导致悲伤成年人的PTSD病原体.
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