在不同地理区域的TCF7L2和CAPN10基因多态和妊娠期糖尿病之间的相关性:一个元分析
Jingjing He1,2,3, Meng Zhang1,2,3, Jianhua Ren4,5,6
1Department of Obstetrics Nursing, West China Second University Hospital, Sichuan University, Chengdu, China.
BMC pregnancy and childbirth
|January 3, 2024
概括
这项元分析发现,特定的TCF7L2和CAPN10基因多态,包括rs7903146,rs12255372,rs7901695,rs290487和rs2975760,与各种人群的妊娠糖尿病 (GDM) 风险有关.
科学领域:
- 遗传学和基因组学 在
- 生殖内分泌学 生殖内分泌学
- 流行病学 流行病学
背景情况:
- 孕期糖尿病 (GDM) 在全球范围内越来越令人担忧.
- 之前对TCF7L2和CAPN10基因多态性和GDM风险的研究已经产生了不一致的结果,这是因为检查的基因位置有限.
- 需要对关键遗传变异进行全面分析,以澄清它们与GDM发病率的关联.
研究的目的:
- 进行已发表研究的系统审查和元分析.
- 调查特定的TCF7L2和CAPN10基因多态化与GDM风险之间的关联.
- 分析跨不同族群的这些关联.
主要方法:
- 在2022年7月之前,在八个主要数据库 (英语和中文) 进行系统的文献搜索.
- 包括39项研究,包括8795例GDM病例和16290例对照.
- 使用几率比率 (OR) 和异质性评估 (I2) 的元分析,以种族和敏感性/出版偏差测试为准,对子组进行分析.
主要成果:
- rs7901695基因型在欧洲 (OR=0.72) 和美国 (OR=0.61) 种群中显示出与GDM的显著关联.
- 对rs12255372,rs7901695,rs290487和rs2975760的等位基因频率在GDM病例和对照组之间存在显著差异.
- 确定了五个特定的位点 (rs7903146,rs12255372,rs7901695,rs290487,rs2975760) 与GDM风险有显著关联.
结论:
- 在TCF7L2基因多态 rs7903146,rs12255372,rs7901695,rs290487和rs2975760与GDM发病率有关.
- 这些发现有助于了解各种人群中对GDM的遗传倾向.
- 进一步的研究可能会探索这些遗传关联背后的功能机制.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Pathophysiology of Diabetes
941
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
941
Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Single Nucleotide Polymorphisms-SNPs
15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K
Incomplete Dominance
22.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
22.6K


