不同剂量的纳尔梅芬与氨酸合剂用于结直肠手术后的术后止痛:一项随机对照研究
1Department of Anaesthesiology, Peking University Shougang Hospital, No.9 Jinyuanzhuang Rd, Shijingshan District, Beijing, 100144, China.
BMC surgery
|January 3, 2024
概括
低剂量纳尔梅芬 (2μg/kg) 结合海德罗摩患者控制的止痛药 (PCA) 显著改善了术后疼痛缓解,并减少了结直肠手术患者的. 这种组合能提供更好的止痛效果,并减少不良事件.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 催化剂为结直肠癌患者提供有效的术后止痛,但具有显著的不良反应.
- 在患者控制的止痛疗法 (PCA) 中,低剂量纳洛与阿片类药物可以减轻与阿片类药物相关的副作用.
- 纳尔梅芬是一种选择性阿片类受体对抗剂,研究了其改善摩PCA的潜力.
研究的目的:
- 评价低剂量纳尔梅芬对摩PCA镇痛功效的影响.
- 评估使用摩-纳尔梅芬PCA的不良事件的发生率,包括恶心,吐和.
- 为了确定纳尔梅芬在结直肠外科手术患者的组合治疗中最佳的剂量.
主要方法:
- 一项随机对照试验,涉及99名接受结肠直肠激进手术的患者.
- 患者接受了甲 (0.15毫克/千克) 与2微克/千克纳尔梅芬 (N1组),0.5微克/千克纳尔梅芬 (N2组) 或没有纳尔梅芬 (C组).
- 疼痛强度 (NRS分数),不良事件和总止痛药消耗在术后48小时内被监测.
主要成果:
- 与对照组相比,N1组 (2μg/kg纳尔梅芬) 在术后12小时和48小时显示疼痛得分明显较低 (P <0.05).
- 在N2组 (0.5μg/kg纳尔梅芬) 和对照组之间没有观察到疼痛评分的显著差异.
- 与对照组相比,纳尔梅芬组的发病率显著减少.
结论:
- 纳尔梅芬剂量为2μg/kg,增强了摩酸的术后止痛作用.
- 纳尔梅芬的2μg/kg剂量也有效地减少了术后的发生.
- 低剂量的纳尔梅芬是一种有前途的补充剂,用于改善胆管直肠手术后患者的治疗结果.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
302
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
302
Analgesia and Pain Management
625
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
625
Opioid Analgesics: Morphine and Other Natural Cogeners
251
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
251
Local Anesthetics: Clinical Application as Epidural Anesthesia
434
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
434
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
88
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
88
Parenteral Anesthetics: Overview
129
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
129


