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一个持续有效的O2供应策略,用于长期调节低氧瘤微环境,以增强长效放射性核酸的内部治疗

Jingchao Li¹, Tingting Wang¹, Yuanfei Shi²

¹Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Journal of nanobiotechnology

|January 3, 2024

概括

这项研究引入了新的2D金纳米薄膜,以持续氧化瘤,增强内部放射治疗 (放射性核素内部放射治疗) 对癌症的有效性. 这种方法克服了瘤缺氧,改善了治疗结果.

科学领域:

生物医学工程生物医学工程
纳米医学是一种纳米医学.
在瘤学瘤学.

背景情况:

内部放射治疗 (RIT) 对癌症有效,但受到瘤缺氧的限制.
现有的基于catalase的纳米材料提供暂时的缺氧缓解,对于RIT的持续时间来说不够.
瘤微环境 (TME) 缺氧降低了RIT的疗效.

研究的目的:

开发一个稳定的纳米平台,用于持续的瘤氧化,以增强RIT.
在RIT中克服缺氧诱导的抵抗.
为了改善癌症治疗,将催化纳米医学与核医学相结合.

主要方法:

制造面部依赖的,类似酶的2D金 (Pd@Au) 纳米片 (NSs).
在TME中利用Pd@Au NSs进行过氧化 (H2O2) 转化为氧气 (O2).
集成的近红外II (NIR-II) 响应和光热疗法 (PTT) 增强功能.

主要成果:

2D Pd@Au NSs表现出一致的H2O2转化为O2,有效地缓解瘤缺氧.
纳米平台提供了持续的氧化,与RIT的治疗持续时间相匹配.
双重作用 (酶和光热) 增强了TME调制和癌症切除.

结论:

面部依赖的2D Pd@Au NSs为持续的瘤氧化提供了一个有希望的策略.
这种方法通过克服缺氧诱导的耐药性,显著提高了RIT的有效性.
纳米医学和核医学的整合推进了癌症治疗,改善了患者的治疗结果.

关键词:

持续的低氧缓解持续的低氧缓解适度的NIR-II光热疗法基于Pd的纳米材料放射性核素内部治疗放射性核素内部治疗

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