伴随性疾病对COPD临床控制标准的影响. 在CLAVE研究中,
Pere Almagro1, Juan José Soler-Cataluña2, Arturo Huerta3
1Multimorbidity Patients Unit. Internal Medicine Department, H. Mutua Terrassa University Hospital, Plaza del Doctor Robert, 5, 08221, Terrassa, Barcelona, Spain. perealmagro@gmail.com.
伴随性疾病显著影响严重慢性阻塞性肺病 (COPD) 的临床控制. 解决这些共同存在的疾病对于改善患者的治疗结果和生活质量至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 慢性阻塞性肺病 (COPD) 经常与其他慢性疾病 (共同疾病) 共存.
- 这些并发症会对COPD的预后,恶化和生活质量产生负面影响.
- 之前的研究没有探讨伴随性疾病对COPD临床控制标准的影响.
研究的目的:
- 确定个性化并发症和COPD临床控制标准之间的关系.
- 为了确定与不良的COPD控制相关的特定并发症.
- 调查伴随性疾病和COPD评估测试成绩和恶化之间的联系.
主要方法:
- 一项观察性,多中心的,横截面研究,涉及4801名患有严重COPD的患者 (FEV1%<50).
- 临床控制被定义为COPD评估测试 (CAT) 分数和前三个月的恶化.
- 用二进制逻辑回归调整年龄和FEV1%,用于识别相关的并发症.
主要成果:
- 最常见的并发病包括动脉高血压,脂质不良,糖尿病和心血管疾病.
- 在调整后,心血管疾病 (心力衰竭,外周血管疾病,心房动),心理障碍 (焦虑,抑郁),代谢疾病 (糖尿病,高血压),睡眠障碍,贫血和胃食道逆流与缺乏COPD临床控制显著相关.
- 这些并发症也与恶化的增加和COPD评估测试得分的降低有关.
结论:
- 伴随性疾病在严重的COPD中普遍存在,并对临床控制产生负面影响.
- 伴随性疾病与与健康有关的生活质量 (通过CAT得分测量) 和恶化病史有关.
- 在严重的COPD患者中调查和治疗并发症对于改善临床控制和生活质量至关重要.
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