基于迷你精神状态检查 (MMSE) 和精神分裂症患者自杀倾向的认知功能的相关性分析和性别差异
Quanfeng Zhu1, Xiang-Yang Zhang2,3
1Affiliated Xiaoshan Hospital, Hangzhou Normal University, 728 Yucai North Road, Hangzhou, 311201, China. quanfengzhu@126.com.
BMC psychiatry
|January 3, 2024
概括
精神分裂症患者的认知功能和自杀倾向显示出性别差异. 认知缺陷与增加自杀风险有关,特别是在男性中,突出显示了潜在的调解作用.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 精神分裂症是一种严重的精神障碍,与认知缺陷和自杀风险增加有关.
- 了解认知和自杀行为之间的相互作用对于有效的治疗策略至关重要.
研究的目的:
- 研究精神分裂症患者的认知功能和自杀倾向之间的相关性.
- 检查这种关系中的性别差异.
主要方法:
- 评估了554名精神分裂症患者的队列.
- 认知功能使用迷你精神状态检查 (MMSE) 进行评估.
- 临床症状和自杀倾向被测量使用积极和消极综合症量表 (PANSS),人际反应率指数 (IRI),多伦多亚历克西西米亚量表 (TAS) 和失眠严重程度指数 (ISI).
主要成果:
- 男性患者显示MMSE得分与自杀倾向之间的相关性.
- 在患有认知功能障碍的男性中,较高的IRI得分和特定的抗精神病药物类型是自杀念头的危险因素.
- 在没有认知功能障碍的男性中,PANSS阳性和一般精神病理学分数是危险因素.
- 在没有认知功能障碍的女性中,PANSS阳性子级分数是自杀念头的危险因素.
结论:
- 在精神分裂症的认知功能和自杀念头之间的关系中存在显著的性别差异.
- 认知功能可能会调解其他因素对这些患者自杀风险的影响.
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