个性化正极呼吸压对胸部外科手术患者手术内氧化的影响:对前性随机对照试验的研究方案
Xu-Ming Liu1, Xin-Lu Chang1, Jing-Yi Sun1
1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing, 100050, China.
Trials
|January 3, 2024
概括
这项研究调查了与标准PEEP相比,个性化正极呼气压 (iPEEP) 是否可以改善氧化和减少单肺通风 (OLV) 期间的并发症. 结果将指导肺部保护性通风策略,以获得更好的患者结果.
科学领域:
- 麻醉学和重症监护医学
- 呼吸系统生理学 呼吸系统生理学
- 胸部外科手术 胸部外科手术
背景情况:
- 单肺通风 (OLV) 经常导致手术期间的低氧化和手术后的肺部并发症 (PPC) 由于分流和透气.
- 已知个性化阳性末尾呼气压 (iPEEP) 可以改善氧化和肺机械,但其在OLV期间的疗效仍未确立.
研究的目的:
- 在接受OLV的患者中,比较iPEEP通风与恒定的5cmH2OPEEP的疗效.
- 评估iPEEP对手术内氧化的影响以及OLV期间PPC的发生率.
主要方法:
- 一项前性,随机对照,单盲试验,涉及112名接受OLV胸腔镜肺切除术的患者.
- 患者被随机分配到静态肺部合规导向的iPEEP定位组 (Cst-iPEEP组) 或常数5cmH2OPEEP组 (PEEP5组).
- 主要结局:OLV后30分钟的氧化指数;次要结局:其他氧化指标,PPC,不良事件和通风器参数.
主要成果:
- 本部分应在研究结果可用后填写.
- 该研究旨在确定Cst-iPEEP是否优于PEEP 5在手术期间的氧化和PPC降低方面.
结论:
- 这项试验将为优化OLV期间肺部保护性通风策略提供临床见解.
- 研究结果旨在通过有效的PEEP管理来改善患者的预后并加速术后康复.
更多相关视频
相关概念视频
Mechanical Ventilation III: Noninvasive Ventilation
124
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
124
Mechanical Ventilation II: Invasive Ventilation
147
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
147
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
216
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
216
Mechanical Ventilation I: Indication and Settings
387
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
387
Oxygen Delivering System III: Tracheostomy and T-piece
988
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
988
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
603
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
603


