相关实验视频

Updated: Jul 6, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

用于口服输送胰岛素的聚合物纳米粒子 (PNP)

Yunyun Wang¹, Hao Li¹, Aamir Rasool²

¹School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green, Processing of Chemical Engineering, Shihezi University, Shihezi, 832003, China.

Journal of nanobiotechnology

|January 3, 2024

概括

聚合物纳米颗粒 (PNP) 显示出口服胰岛素输送的前景,克服了低生物可用性等挑战. 本综述指导了对PNP用于增强糖尿病管理的未来研究.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

糖尿病管理严重依赖于胰岛素注射,影响患者的生活质量.
由于胃肠道障碍,目前口服胰岛素的生物可用性严重受限 (≤2%).
聚合物纳米粒子 (PNPs) 为口服胰岛素提供了一个有前途的技术解决方案.

研究的目的:

审查用于口服胰岛素输送的聚合物纳米粒子 (PNPs) 的最新进展.
总结控制释放机制和PNP在口服胰岛素输送中的最新应用.
概述PNP在提高口服胰岛素生物利用性方面的挑战和未来前景.

主要方法:

文献综述侧重于最近关于PNP用于口服胰岛素输送的研究文章.
对PNP使用的受控释放机制的分析.
评估PNP纳米载体的当前应用和未来潜力.

主要成果:

聚合物纳米粒子 (PNPs) 显示出克服口服胰岛素胃肠道障碍的巨大潜力.
各种PNP配方表现出增强的胰岛素负载和受控释放特征.
最近的研究强调PNP在改善口服胰岛素生物可用性的有效性.

结论:

PNPs代表了一种非常有前途的纳米载体系统,用于有效的口服胰岛素输送.
进一步的研究和开发对于应对挑战和优化基于PNP的口服胰岛素配方至关重要.
本综述为糖尿病治疗PNP领域的未来研究人员提供了一份路线图.

关键词:

有控制释放的释放.糖尿病患者糖尿病患者胰岛素是一种胰岛素.这是口头传递.聚合物纳米颗粒 (PNP) 是一种

更多相关视频

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

相关概念视频

Insulin Formulations: Types and Delivery

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...

Oral Hypoglycemic Agents: Glinides

Oral Hypoglycemic Agents: Glinides

Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...

Insulin: Biosynthesis, Chemistry, and Preparation

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...