中年2型糖尿病患者认知障碍的危险因素:一个横截面研究
Yao-Shuang Li1,2, Jing-Bo Li2, Jun-Jia Wang2,3
1Tianjin Union Medical Center, Tianjin Medical University, Heping, Tianjin, China.
BMJ open
|January 3, 2024
概括
认知障碍 (CI) 影响38.9%的中年糖尿病患者. 风险因素包括年龄和腰围,而肥胖和教育是保护性的. 体重指数和腰围的结合预测了CI.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 认知障碍 (CI) 在老年人群中越来越令人担忧,特别是在2型糖尿病 (T2DM) 患者中.
- 中年T2DM患者是调查认知衰退早期风险因素的关键人口.
- 了解代谢健康,特别是肥胖和认知功能之间的相互作用,对于有针对性的干预至关重要.
研究的目的:
- 鉴定2型糖尿病 (T2DM) 的住院中年患者的认知障碍 (CI) 相关的风险因素.
- 为了探索肥胖指标 (BMI,WC) 和这个患者队列的认知功能之间的关系.
- 评估早期CI查中肥胖指标的预测价值.
主要方法:
- 将患者分类为正常认知功能 (NCF) 和CI组,使用MoCA和MMSE.
- 使用后勤回归和通用线性建模来确定CI风险因素.
- 利用线性回归,断片回归和相互作用分析来检查肥胖参数 (BMI,WC) 和认知能力之间的关联.
主要成果:
- 在住院的中年T2DM患者中,CI的患病率为38.9% (中位数为58岁).
- CI的独立风险因素包括年龄,腰围 (WC),最近的低血糖发作和脑血管疾病 (CVD).
- 独立的保护因素是高等教育,坚持糖尿病饮食模式,超重或肥胖. 对于MoCA分数,BMI显示在特定范围内的保护作用,而WC则是MMSE和MoCA分数的风险因素. BMI 和 WC 的综合 AUC 为 0.754.
结论:
- 年龄,学历,糖尿病饮食,卫生保健,超重,肥胖,近期低血糖症和心血管疾病是中年T2DM患者CI的潜在影响因素.
- BMI和WC的组合显示为预测该人口早期CI查的预测指标.
- 需要进一步的前性研究来验证这些发现并为临床实践提供信息.
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