慢性催产素的使用刺激了自闭症儿童的催产素系统
Matthijs Moerkerke1,2, Nicky Daniels2,3, Laura Tibermont1,2
1Center for Developmental Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Nature communications
|January 3, 2024
概括
针对儿童自闭症的鼻内催产素治疗增加了催产素水平,并减少了基因甲基化,表明了内源性催产素作用系统的刺激. 这些效应在治疗四周后被观察到.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 药理学 药理学是指药理学的学科.
- 遗传学 是一个遗传学.
背景情况:
- 鼻内催产素正在被用于自闭症谱系障碍 (ASD).
- 慢性催产素对ASD内源性催产素作用的生物效应在很大程度上是未知的.
研究的目的:
- 研究慢性鼻内催产素给药对自闭症儿童内源性催产素作用的生物学影响.
- 评估唾液中催产素水平的变化,催产素受体基因 (OXTR) DNA甲基化,以及它们与附着的关联.
主要方法:
- 与自闭症儿童 (n=79) 进行随机化,安慰剂对照试验.
- 四周的鼻内催产素 (12 IU,每天两次).
- 测量包括唾液中催产素水平,OXTR DNA甲基化和依附评估在基线,治疗后和四周随访.
主要成果:
- 与安慰剂相比,接受鼻内催产素的儿童在治疗后24小时内表现出明显更高的唾液催产素水平.
- 催产素的使用导致OXTR DNA甲基化减少,这表明催产素受体表达增加.
- 治疗后增加的催产素水平与减少的OXTR DNA甲基化和改善的安全附着相关.
结论:
- 四周的慢性鼻内催产素给药刺激了自闭症儿童的内源性催产素系统.
- 观察到的表观遗传变化 (OXTR DNA甲基化) 表明了催产素在ASD中的作用的潜在机制.
- 这些发现支持进一步研究催产素对ASD的治疗潜力.
更多相关视频
09:12Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
Published on: November 14, 2018
7.9K
07:30Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
Published on: June 10, 2013
24.8K
相关概念视频
Autism Spectrum Disorder
99
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
99
Modeling in Therapy
84
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
84
Operant Conditioning Intervention
58
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
In operant conditioning, behaviors that are...
58
Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68
Oppositional Defiant Disorder
25
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
25
