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Updated: Jul 6, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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突变的p53通过染色体不稳定性诱导的细胞核DNA反应获得致癌功能

Mei Zhao1, Tianxiao Wang1,2, Frederico O Gleber-Netto1

  • 1Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Nature communications
|January 3, 2024
PubMed
概括

突变的p53蛋白通过准MCM来获得促进癌症的功能,导致复制应激和DNA反应. 这促进了瘤转移和免疫抑制的微环境,影响了癌症的进展.

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