在第一期抗精神病原始精神分裂症中,状体体积扩大
Jiaxin Zeng1,2,3, Tianwei Zhang2,4, Biqiu Tang1,2,3
1Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Schizophrenia (Heidelberg, Germany)
|January 3, 2024
概括
精神分裂症患者有扩大状交体积,这一发现可能与神经炎症有关. 这种扩大似乎是一种持久的特征,不受抗精神病治疗或疾病持续时间的影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 冠状动脉与神经炎症和精神分裂症中大脑功能障碍有关.
- 以前的研究仅限于包括接受治疗的患者和长期疾病,混胆结合体的发现.
研究的目的:
- 为了研究第一个情节,抗精神病素质的精神分裂症患者的胆管体体积.
- 为了确定胸膜扩大是否是精神分裂症的特征标志物,独立于治疗和疾病持续时间.
主要方法:
- 在120名第一发作抗精神病原始精神分裂症患者和120名健康对照人群中进行了高分辨率的结构性脑部扫描.
- 手动提取状体体积,控制年龄,性别和内体积.
- 评估了状体体积和大脑结构,症状严重程度和认知功能之间的相关性.
主要成果:
- 与健康对照人群相比,精神分裂症患者表现出明显扩大的胆管体体积.
- 状体体积与患者的年龄呈正相关性,在两组中,男性的体积比女性更大.
- 状体体积仅与侧腔室体积有显著的相关性,而与临床或认知测量无关.
结论:
- 胸膜体积增加是精神分裂症的一个潜在的持久性特征,即使在抗精神病治疗前的第一个发作中也可以观察到.
- 这一发现表明,状在精神分裂症的病理生理学中可能发挥作用,独立于治疗和疾病过程.
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