甲状腺皮层连接的发展和演变.
Zoltán Molnár1, Kenneth Y Kwan2
1Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford OX1 3PT, United Kingdom zoltan.molnar@dpag.ox.ac.uk kykwan@umich.edu.
Cold Spring Harbor perspectives in biology
|January 3, 2024
概括
thalamus 和皮质之间的大脑连接的发展依赖于导航进化修饰的区域. 本综述探讨了皮层轴突指导如何通过上下上边界是由进化和发展塑造的.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 进化生物学 进化生物学
背景情况:
- 哺乳动物的意识感知依赖于复杂的大脑皮层-脑丘脑连接.
- 这些结构的发展和演变是紧密联系在一起的.
- thalamocortical轴突 (TCA) 路径查找涉及导航前脑区域具有显著的进化分歧,特别是皮-亚皮边界 (PSPB).
研究的目的:
- 审查指导 thalamocortical轴突 (TCAs) 跨越前脑边界的机制.
- 为了检查下边界 (PSPB) 对TCA路径的进化影响.
- 讨论神经发育过程中丘脑和皮质之间的相互影响.
主要方法:
- 审查现有的文学关于thalamocortical发展和演变.
- 对指导轴突路径的细胞和分子机制的分析.
- 跨物种前脑组织的比较分析.
主要成果:
- 哺乳动物前脑发育涉及过渡性细胞群和指导TCA的亚板神经元.
- 经过进化修改的部-下部边界 (PSPB) 为TCA导航带来了独特的挑战和机制.
- 皮层区域最初是由遗传因素塑造的,随后通过thalamocortical输入进行了改进.
结论:
- 了解TCA指导机制对于理解大脑发育和进化至关重要.
- 在PSPB的进化修改显著影响thalamocortical电路形成.
- 遗传模式和轴突输入之间的相互作用塑造皮质组织和功能.
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