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在美国成年人中,肉类和骨关节炎之间的关联:一个横截面研究
Peng Peng1, Jiawei Wu1, Weihua Fang1
1Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Scientific reports
|January 3, 2024
概括
低肌肉质量的状况 - - 萨科佩尼亚 - - 与美国成年人患骨关节炎 (OA) 的风险更高有关. 这种关联在吸烟者中特别强烈,突出了OA发展的潜在风险因素.
科学领域:
- 老年学是指老年学的学科.
- 类风湿病学 类风湿病学
- 公共卫生 公共卫生
背景情况:
- 骨关节炎 (OA) 是一种常见的退行性关节疾病,具有重大公共卫生影响.
- 肌肉质量低的萨尔科佩尼亚与OA之间的关系尚未完全理解,需要进一步调查.
研究的目的:
- 在美国成年人代表性样本中调查缩症和骨关节炎的发生之间的关联.
- 探索潜在的改变因素,如吸烟状态,在萨尔科佩尼亚和OA之间的关系.
主要方法:
- 这是一项横截面研究,利用了国家健康和营养检查调查 (1999-2006) 的11,456名参与者的数据.
- 使用低骨肌肉指数 (SMI) 定义了萨科佩尼亚,该指数是用身体质量指数 (BMI) 调整或体重调整的尾骨肌肉量计算的.
- 骨关节炎状态通过自我报告问卷来确定,并使用多变量回归模型分析关联.
主要成果:
- 麻症与骨关节炎的可能性增加显著相关,不管SMI调整方法 (BMI调整:OR=1.23,P=0.038;体重调整:OR=1.30,P=0.003).
- 亚组分析显示,在吸烟者 (OR=1.54,P=0.006) 中,缩症和OA之间的关联明显更强.
- 在非吸烟者或其他分析的小组中,这种关联并不显著.
结论:
- 萨科佩尼亚与美国成年人骨关节炎的发生有关.
- 吸烟似乎加剧了sarcopenia和OA之间的关系,这表明有协同效应.
- 需要进一步的前性研究来证实这些发现并阐明潜在的机制.
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