通过调节细胞分化,培养肉具有丰富的感官特性
Milae Lee1, Sohyeon Park1, Bumgyu Choi1
1Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Nature communications
|January 3, 2024
概括
这项研究通过控制支架上的细胞分化来增强培养肉,改善感官和营养质量,以模仿传统牛肉. 这种方法侧重于有机感特性,以获得更好的食品特性.
科学领域:
- 食品科学 食品科学 食品科学
- 生物技术是生物技术.
- 组织工程是组织工程.
背景情况:
- 培养肉的研究往往优先考虑细胞增殖而不是感官属性.
- 体感特征是肉质和消费者接受度的关键决定因素.
- 缺乏研究的食品特性限制了当前培养肉的市场潜力.
研究的目的:
- 为了研究控制培养肉的感官和营养特性.
- 通过架构工程来定制细胞分化,以改善食品特性.
- 为了制造具有与传统牛肉相似的感觉配置的培养肉.
主要方法:
- 采用了初级牛肉肌细胞和脂肪衍生的介质干细胞的二维分化.
- 采用不同硬度的凝/酸盐支架来控制细胞分化.
- 评估了肌肉和脂肪分化质量对感官特性的影响.
- 组装的分化细胞结构,以制造最终的培养肉制品.
主要成果:
- 证明了脚手架的刚性会影响肌肉和脂肪分化的质量.
- 展示了细胞分化质量与培养肉的感官特性之间的相关性.
- 成功制造出具有与传统牛肉相似的感官配置文件的培养肉.
- 确定了特定的差异化策略,以增强食品的特性.
结论:
- 脚手架工程是一种可行的策略,可以调节细胞分化并增强培养肉的食物特性.
- 定制细胞分化对于在培养肉中实现所需的感官和营养特征至关重要.
- 这项研究为生产有味道的培养肉提供了途径,这种肉类非常类似于传统的牛肉.
相关概念视频
iPS Cell Differentiation
2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K
Cell Culture
17.2K
Most vertebrate cells grow in vitro attached to a substrate as a monolayer, called adherent cultures. The flasks and plates used to grow cells are chemically treated to facilitate cell attachment. However, a few cell types, such as hematopoietic cells, can grow in a suspension. In contrast to adherent cultures, suspension cultures can grow in non-treated cultureware using magnetic stirrers or spinner flasks to agitate the culture media
17.2K
Transgenic Organisms
31.2K
Overview
31.2K
Cellular Differentiation
2.7K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
2.7K
Forced Transdifferentiation
1.9K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
Artificial...
1.9K


