一个随机的,受控的临床研究低分子量肝素改善怀孕结果在PCOS妇女接受试管婴儿:研究协议
Ou Huang1, Haixia Ding2,3, Dandan Wu4,5
1Department of General Surgery, Comprehensive Breast Health Center, Ruijing Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Trials
|January 3, 2024
概括
这项研究调查了低分子量肝素 (LMWH) 是否改善了经过IVF-FET的多囊性卵巢综合征 (PCOS) 妇女的怀孕结果. 这项研究旨在确定LMWH是否减少了早期怀孕损失,并增加了这一群体的活产率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 血栓形成和血液静止.
- 不孕症治疗 不孕症治疗
背景情况:
- 多囊卵巢综合征 (PCOS) 影响10-15%的生殖年龄妇女,增加了3-8倍的早期怀孕损失风险.
- 结核复合综合症与前血栓状况和免疫系统过度激活有关,导致不良妊娠结果.
- 用低分子量肝素 (LMWH) 进行抗凝固治疗是减轻这些风险的潜在策略,尽管在怀孕早期对PCOS的使用尚未研究.
研究的目的:
- 调查LMWH作为辅助疗法的疗效,以改善经过体外受精-冷胚胎移植 (IVF-FET) 的PCOS妇女的妊娠结果.
主要方法:
- 一项随机对照试验,涉及356名年龄在20-38岁的PCOS妇女,接受试管婴儿-FET.
- 参与者被分为接受LMWH的研究组和接受标准激素治疗的控制组.
- 主要结局是正在进行的怀孕,定义为怀孕12周后超声波上的活胎儿.
主要成果:
- 该研究方案旨在在LMWH和对照组之间比较正在进行的怀孕率,临床怀孕率,活产率和早期怀孕丧失率.
- 生物化学怀孕将在胚胎移植后14天得到确认,两周后通过超声波确认子宫内怀孕.
结论:
- 这项研究是第一个评估LMWH在接受IVF-FET的PCOS患者的疗效的方案.
- 这些发现将提供关于LMWH在改善IVF-FET成功率和减少PCOS妇女怀孕并发症中的作用的关键数据.
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