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Updated: Jul 6, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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新型贝林衍生物作为针对P-糖蛋白的多药逆转剂

Jerónimo Laiolo1, Dafni G Graikioti2, Cecilia L Barbieri3

  • 1Fine Chemical and Natural Products Laboratory, IRNASUS CONICET-UCC, Universidad Católica de Córdoba, Córdoba, Argentina.

Scientific reports
|January 3, 2024
PubMed
概括

新的贝林类型被开发用于抑制P-glycoprotein (P-gp),这是癌症化疗期间多药耐药性 (MDR) 的关键因素. 化合物6g和6i在恢复化疗敏感性方面表现有希望,而不会对正常细胞产生毒性.

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