越南儿童患有严重和不严重的肺炎的病毒和细菌微生物
Xuan Duong Tran1,2,3, Van-Thuan Hoang1, Ndiaw Goumballa2
1Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam.
Scientific reports
|January 3, 2024
概括
儿童的社区性肺炎 (CAP) 通常是由多种病原体引起的. 呼吸道综合体病毒 (RSV) 和Hemophilus influenzae增加了严重疾病的风险,需要密切监测.
科学领域:
- 儿童传染病 儿童传染病
- 呼吸系统医学 呼吸系统医学
- 微生物学 微生物学
背景情况:
- 社区获得性肺炎 (CAP) 是儿童疾病的重要原因之一.
- 识别严重的CAP的致病因子和风险因素对于有效管理至关重要.
- 之前的研究强调了小儿肺炎中涉及的微生物病原体的复杂性.
研究的目的:
- 在被诊断患有CAP的儿童中调查呼吸道病原体的频谱.
- 确定与儿科患者严重CAP发展相关的风险因素.
- 分析特定微生物检测和疾病严重程度之间的相关性.
主要方法:
- 越南儿科医院的一项前性研究涉及467名患有CAP的儿童.
- 使用实时PCR分析的鼻抽样检测了24种呼吸道微生物.
- 使用后勤回归分析来确定严重疾病风险因素的调整奇数比率.
主要成果:
- 超过97%的患者至少有一种微生物的检测结果呈阳性;87%的患者有多种病原体.
- 最常见的病毒包括犀牛病毒 (46%),呼吸道共囊病毒 (RSV) (24%) 和肠道病毒 (17%).
- 发现的常见细菌包括Hemophilus influenzae (61%),Streptococcus pneumoniae (45%),以及Moraxella catarrhalis (30%).这些细菌是最常见的.
- 严重的肺炎 (27%的病例) 与家庭吸烟暴露,高CRP水平,RSV和H. influenzae检测有关.
结论:
- 儿科CAP经常是由病毒和细菌病原体的复杂混合引起的.
- RSV和H. influenzae感染是儿童严重肺炎的重要危险因素.
- 密切监测感染RSV和H. influenzae的儿童是必要的,以防止严重的结果.
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