发作的发生和决定因素及其对结核性脑膜炎的影响:前性评估
Roopesh Singh Kirar1, Ravi Uniyal2, Ravindra Kumar Garg1
1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, 226003, India.
Acta neurologica Belgica
|January 3, 2024
概括
发作影响了超过三分之一的结核性脑膜炎 (TBM) 患者,皮质干扰是关键预测因素. 焦点发作和状态显著恶化了TBM患者的结果.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经成像是一种神经成像.
背景情况:
- 结核性脑膜炎 (TBM) 是一种严重的肺外结核病.
- 发作是TBM的一个常见的神经并发症,影响患者的预后.
- 了解发病率和相关因素对于改善TBM管理至关重要.
研究的目的:
- 确定诊断为TBM的患者中发作的发生率.
- 为了确定与发作发生相关的临床,神经成像和电脑学因素.
- 调查TBM患者发作不良结果的预测因素.
主要方法:
- 一项前性观察性研究在两年内招募了129名TBM患者.
- 收集的数据包括临床病史,神经学检查,实验室测试,MRI和EEG.
- 患者接受了治疗并被跟踪了六个月,结果使用修改后的Rankin尺度进行评估.
主要成果:
- 发作发生在37.2%的TBM患者中.
- 先进的TBM阶段,MRI上皮质干涉和EEG形放电与发作有关.
- 皮层干涉是发作的独立预测因素.
- 焦点到双边发作,状态,和利芬素耐药性预测了糟糕的6个月的结果.
结论:
- 在TBM中,发作与疾病的严重程度和特定的神经成像/EEG发现有关.
- 焦点发作到双边发作和状态的发生会对患者的结果产生负面影响.
- 识别这些风险因素可以指导有针对性的干预措施,并改善TBM的预后.
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