在新生儿中使用曼南抗原试验的评估,有或没有Candida albicans的殖民化
Vasiliki Bourika1, Tania Siahanidou1, Kalliopi Theodoridou2
1Neonatal Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece.
Medical mycology
|January 3, 2024
概括
曼南抗原 (MA) 测试显示,在新生儿中检测入侵性候选血症的特异性很高. 这种诊断标志物可以帮助识别高风险婴儿严重的Candida感染.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 侵袭性白血病是新生儿重症监护室 (NICU) 的一个严重问题.
- 在Candida spp. 感染影响4%的NICU入院.
- 曼南抗原 (MA) 作为新生儿入侵性白血病的标志物尚未得到研究.
研究的目的:
- 为了评估曼南抗原 (MA) 测试的诊断性能.
- 评估MA在新生儿的实用性与直肠Candida殖民与对照.
- 在新生儿群体中确定PlateliaTM Candida AgPlus套件的特异性.
主要方法:
- 一项涉及340名新生儿的病例控制研究.
- 结直肠抽样进行培养,以识别Candida殖民.
- 使用PlateliaTM Candida AgPlus套件测量了曼南抗原 (MA) 的水平.
主要成果:
- 在新生儿中,MA检测显示出96%的特异性,这些新生儿有*C. albicans*直肠殖民 (24/25阳性).
- 在非殖民新生儿中,MA测试显示100%的特异性 (30/30阳性).
- 该试验在评估的新生儿队列中表现出高特异性.
结论:
- 曼南抗原 (MA) 测试具有高特异性,用于诊断新生儿的侵入性候选血症.
- 普拉特利亚TM Candida AgPlus套件显示出作为一种有价值的诊断工具的潜力.
- 这种测试可以帮助临床医生识别风险新生儿的候选血症.
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