肠道微生物群促进慢性自发性疹
Lei Zhu1,2,3, Xingxing Jian4, Bingjing Zhou1,2,3
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Nature communications
|January 3, 2024
概括
慢性自发性疹 (CSU) 中的肠道失调包括减少短链脂肪酸和增加脂多糖. 这些变化促进皮肤炎症,但Roseburia hominis和Caproate提供了保护.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 慢性自发性疹 (CSU) 与肠道失调有关,但具体机制和临床相关性尚未完全理解.
- 肠道微生物群的改变可能会影响CSU患者的全身炎症和疾病活性.
研究的目的:
- 研究肠道失调的作用,特别是短链脂肪酸 (SCFA) 生产和细菌组成,在CSU的发病过程中.
- 评估CSU相关的肠道微生物群和特定细菌对巨细胞驱动的皮肤炎症和肠道透性的影响.
主要方法:
- 使用元基因组学测序和SCFA代谢学来分析CSU患者的肠道微生物群.
- 人类CSU便微生物移植和特定细菌 (Klebsiella pneumoniae,Roseburia hominis) 移植在小鼠模型中进行.
- 评估了对皮肤炎症,肠道透性和脂多糖化物 (LPS) 水平的影响.
主要成果:
- 在CSU肠道微生物群中,多样性较低,SCFA产量减少,Klebsiella pneumoniae水平升高,与疾病活性和较低的血液SCFA水平相关.
- 在CSU患者中观察到血中LPS水平升高,与快速复发和高水平的肠道条件病原体有关.
- 在小鼠中,CSU微生物组转移和K. pneumoniae移植加剧了IgE介导的大细胞驱动的皮肤炎症,增加了肠道透性和LPS积累.
结论:
- 在CSU的肠道失生症的特征是SCFA的减少和LPS的增加,这有助于巨细胞驱动的皮肤炎症.
- 移植Roseburia hominis和施用卡普罗酸在接受者小鼠中显示出对皮肤炎症的保护作用.
- 针对肠道微生物群和SCFA等代谢物,为CSU提供了一个潜在的治疗策略.
相关概念视频
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
430
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
430
01:17Irritable Bowel Syndrome I: Introduction
277
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
277
01:17Gastritis-II: Pathophysiology
337
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
337
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
592
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
592
01:30Peptic Ulcer Disease I: Introduction
173
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
173
01:17Chronic Bowel Disorders: Introduction
455
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
455