评估患者导向湿疹测量 (POEM) 结果中的测量错误
Ariane Duverdier1,2,3, Guillem Hurault1, Kim S Thomas4
1Department of Bioengineering, Imperial College London, London, UK.
概括
使用患者导向湿疹测量 (POEM) 患者回忆阿托皮炎 (AD) 症状显示偏差较低,但噪音较高. 这意味着POEM得分可能因记忆不完善而有很大差异,影响解释.
科学领域:
- 皮肤病学 皮肤病学
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 面向患者的湿疹测量 (POEM) 是评估亚托皮炎 (AD) 症状的核心工具.
- POEM依赖于患者在前七天内回忆起七个关键症状.
研究的目的:
- 为了评估来自不完美的患者回忆的POEM记录中的测量错误.
- 在POEM症状报告中量化回忆偏差和回忆噪声.
主要方法:
- 分析了247名年龄在12-65岁之间的亚托皮性皮肤炎患者的数据.
- 在777个患者周内,回忆POEM分数 (r-POEM) 与每日POEM分数 (d-POEM) 的比较.
- 应用统计模型来估计回忆偏差和噪声.
主要成果:
- 在POEM分数中,回忆偏差很低,但回忆噪声很高.
- 召回噪声导致潜在得分变化为5.7分.
- 患者倾向于高估和干燥回忆,低估其他症状,如出血和睡眠障碍.
结论:
- 患者对POEM的召回显示出显著的变化 (高噪音),尽管系统偏差很低.
- 在临床实践中解释POEM分数时,大量的回忆噪声需要仔细考虑.
- 这些发现突显了记忆缺陷对患者报告的结果措施在亚托皮性皮炎研究中的影响.
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