相关实验视频

Updated: Jul 6, 2025

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

基于矩阵的分子机制,向和诊断在口腔状细胞癌的诊断

Nicholas S Mastronikolis¹, Efthymios Kyrodimos², Zoi Piperigkou^3,4

¹Department of Otorhinolaryngology - Head and Neck Surgery, School of Medicine, University of Patras, Patras, Greece.

|January 3, 2024

概括

口腔状细胞癌 (OSCC) 是一种致命的癌症. 本综述探讨了细胞外矩阵 (ECM) 如何影响OSCC发育和转移,突出了关键的分子参与者.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

口腔状细胞癌 (OSCC) 是一种普遍存在的头癌,具有显著的死亡率.
OSCC转移受各种病因因素和分子机制的影响.
细胞外基质 (ECM) 在调节细胞功能,侵袭和癌症转移方面发挥着至关重要的作用.

研究的目的:

审查最近关于ECM宏分子效应因子在OSCC发展中的参与的研究.
讨论蛋白质甘氨酸,整体蛋白和矩阵金属蛋白酶在OSCC进展中的特定作用.
阐明ECM在调节OSCC病原性中的作用的不太了解的方面.

主要方法:

对近期研究成果的批判性文献综述.
分析涉及OSCC中ECM组件的分子机制.
讨论癌细胞,纤维细胞和瘤微环境 (TME) 矩阵之间的相互作用.

主要成果:

在OSCC中,ECM的组成和功能与正常组织有很大的不同.
癌细胞与纤维细胞一起,在TME中为瘤基质做出贡献.
特定的ECM分子,如蛋白质甘氨酸,整体蛋白和矩阵金属蛋白酶,都与OSCC入侵和转移有关.

结论:

ECM是OSCC发展和进展的关键调节器.
需要进一步的研究,以充分理解在OSCC中ECM组件的复杂作用.
准ECM相互作用为OSCC提供了潜在的治疗策略.

关键词:

皮质转化为介质酶的过渡.细胞外矩阵是细胞外矩阵.头部和部癌症头部和部癌症矩阵金属蛋白质酶是什么口腔状细胞癌的癌症.瘤微环境是一个微环境.

更多相关视频

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...