心胸重症监护后的阿片类药物使用:风险因素和结果:一项队列研究
Erik von Oelreich1,2, Francesca Campoccia Jalde3,4, Susanne Rysz3,4
1Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Stockholm, Sweden. erik.von.oelreich@ki.se.
Scientific reports
|January 3, 2024
概括
滥用阿片类药物是一种公共卫生危机. 一项研究发现,心胸重症监护室 (ICU) 超过11%的患者持续使用阿片类药物,使其死亡风险增加了两倍以上.
科学领域:
- 关键护理医学 关键护理医学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 滥用阿片类药物是一个重大的公共卫生挑战.
- 心胸重症监护室 (ICU) 的患者经常接触阿片类药物,但慢性使用的长期后果尚不清楚.
- 了解ICU后持续使用阿片类药物对于患者的治疗结果至关重要.
研究的目的:
- 为了描述心胸ICU入院后的阿片类药物使用模式.
- 确定与持续使用阿片类药物相关的因素.
- 分析持续使用阿片类药物与死亡风险之间的关联.
主要方法:
- 一项回顾性队列研究,利用瑞典2010-2018年国家数据.
- 包括34,200名心胸科ICU护理患者的病例.
- 分析持续使用阿片类药物,相关因素和离 ICU 退院后 24 个月的死亡率.
主要成果:
- 4,050名患者 (11.8%) 在ICU后持续使用阿片类药物.
- 与持续使用相关的因素包括年龄较小,先前的阿片类药物使用,女性性别,并发症和早期入院年.
- 持续使用阿片类药物与在ICU入院6-18个月后死亡风险增加2.2倍 (调整后的危险比率) 有关.
结论:
- 持续的阿片类药物使用在心胸病房ICU护理后很常见,并且与明显更高的死亡率有关.
- 确定了持续使用阿片类药物的预测因素,突出了脆弱的患者子组.
- 高度阿片类药物消费持续长期,即使没有明确的证据表明延长治疗,需要进一步调查和干预策略.
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