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Updated: Jun 27, 2026

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人类热细胞干细胞限制人细胞巨核病毒的复制

Tyler B Rollman, Zachary W Berkebile, Hiroaki Okae

    bioRxiv : the preprint server for biology
    |January 3, 2024
    PubMed
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    人类细胞巨乳病毒 (HCMV) 对胎盘干细胞的感染限制了病毒复制,但破坏了热囊细胞的分化,可能会影响怀孕的结果. 这项研究使用人类热囊细胞干细胞模拟了早期的胎盘HCMV感染.

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    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...