晶素2保护T细胞脂质代谢编程和抗瘤功能
Sung-Min Hwang1,2, Deepika Awasthi1,2, Jieun Jeong3
1Department of Obstetrics and Gynecology, Weill Cornell Medicine. New York, NY 10065, USA.
Research square
|January 3, 2024
概括
转素2 (TAGLN2) 通过调节脂肪酸吸收,对CD8+T细胞代谢和抗癌免疫非常重要. 在T细胞中恢复TAGLN2可以克服瘤诱导的功能障碍,并增强癌症免疫疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞的新陈代谢
- 癌症生物学 癌症生物学
背景情况:
- 针对瘤的有效免疫力需要T细胞通过细胞外脂肪酸进行代谢编程.
- 脂肪酸结合蛋白5 (FABP5) 进口脂质,为T细胞的呼吸和能量需求提供燃料.
- 控制这种免疫代谢途径的精确机制尚不清楚.
结论:
- 在ER压力T细胞中恢复TAGLN2可增强其代谢功能和细胞毒性能力.
- 在CAR T细胞中过度表达TAGLN2提高了转移性卵巢癌模型中的治疗疗效.
- 在T细胞脂质代谢中TAGLN2的作用为增强固体瘤细胞免疫治疗提供了潜在的标.
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