在男性中,BMI和BPH与尿路微生物群多样性和下尿路症状相关
Kate R Bowie1,2, Mark Garzotto3,4, Eric Orwoll5
1Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.
bioRxiv : the preprint server for biology
|January 3, 2024
概括
男性的尿道微生物组与良性前列腺增生 (BPH) 和体重指数 (BMI) 有关. 这些因素会影响老年男性下泌尿道症状 (LUTS) 和微生物多样性.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年学是一门学科.
背景情况:
- 尿路微生物组与感染不同,在女性中被识别,并与下尿路症状 (LUTS) 相关.
- 关于男性尿道微生物组的研究有限,特别是在大型队列中,这阻碍了对其在男性泌尿健康中的作用的理解.
研究的目的:
- 为了研究尿路微生物组合及其与老年男性下尿路症状 (LUTS) 的关联.
- 探索男性尿道微生物群,良性前列腺增生 (BPH) 和体重指数 (BMI) 之间的关系.
主要方法:
- 来自男性骨质疏松性骨折 (MrOS) 研究的500名65-90岁男性的尿道微生物组分析.
- 检查微生物多样性指标,BPH,BMI和LUTS之间的关联.
主要成果:
- 在良性前列腺增生 (BPH),年龄和体重指数 (BMI) 与尿道微生物群多样性之间发现了显著的关联.
- 在BMI,BPH,LUTS和α多样性之间出现了复杂的相互关系,表明了复杂的尿道微生物组动态.
结论:
- 男性的尿道微生物群受到BPH,年龄和BMI的影响,影响LUTS.
- 了解这些相互关系对于设计未来关于男性尿道微生物群异质性的研究至关重要.
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