使用双胞胎对来评估多基因预测在整个发展过程中外部化行为的潜在偏差
Joanna K Bright1, Christopher Rayner1, Ze Freeman2
1Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, Kings College London.
medRxiv : the preprint server for health sciences
|January 3, 2024
概括
对外部化行为的多基因分数准确地预测行为和ADHD症状,基因环境相关性对基因环境的混最小. 这些遗传预测显示了有限的偏见,反映了直接的遗传影响.
科学领域:
- 行为遗传学行为遗传学
- 精神病学遗传学 精神病学遗传学
- 发展心理学是发展心理学.
背景情况:
- 多基因分数 (PS) 预测复杂的特征,但可能会被被动基因环境相关性 (rGE) 混.
- 了解直接的遗传影响与rGE对准确的遗传预测在行为研究至关重要.
- 外向化行为,如行为问题和ADHD具有重要的遗传成分.
结论:
- 外化多基因分数是对行为和ADHD直接遗传影响的可靠指标,基本上没有rGE偏差.
- 虽然rGE对预测的影响很小,但一些间接的遗传影响影响了行为问题的稳定性.
- 需要进一步的研究,以充分阐明CU特征的遗传结构.
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