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大规模的平行基编辑屏幕将变异效应映射到原始人类T细胞的抗瘤特征上

Zachary H Walsh, Parin Shah, Neeharika Kothapalli

    bioRxiv : the preprint server for biology
    |January 3, 2024
    PubMed
    概括

    我们开发了一种用于初级人类T细胞的高通量基编辑屏幕,使得大规模发现基因变异能够增强T细胞抗瘤免疫力和免疫疗法. 这种方法有效地识别了有利于改善T细胞功能和癌症治疗的有益突变.

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    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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