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相关概念视频

Somatosensation01:33

Somatosensation

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The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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相关实验视频

Updated: Jul 6, 2025

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
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在手臂截肢之前和之后的稳定皮质身体地图.

Hunter R Schone1,2,3,4, Roni O Maimon Mor1,5,6, Mathew Kollamkulam1,7

  • 1Institute of Cognitive Neuroscience, University College London, London, UK.

bioRxiv : the preprint server for biology
|January 3, 2024
PubMed
概括

在截肢手臂后,成年大脑的重组是有争议的. 新的研究表明,手和嘴唇的皮层表征稳定,这表明截肢不会导致大规模的大脑变化.

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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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科学领域:

  • 神经科学是一个神经科学.
  • 神经可塑性 神经可塑性
  • 脑部成像 脑部成像

背景情况:

  • 成人大脑在受伤后重新组织 (神经可塑性) 的能力,如截肢,是研究的一个关键领域.
  • 之前的研究,包括动物模型,表明肢体损失后皮质重组显著.

研究的目的:

  • 为了调查手臂截肢是否会导致成年人大脑的大规模皮质重组.
  • 使用纵向神经成像来比较截肢前后的大脑活动模式.

主要方法:

  • 在三个成年参与者中使用了纵向神经成像 (fMRI).
  • 在截肢手臂前和截肢手臂5年后测量皮质活动.
  • 他们比较了大脑对想象的手部运动 (截肢前) 和幻手部运动 (截肢后) 的反应,以及唇部运动.

主要成果:

  • 观察到手和嘴唇运动的稳定皮质表示.
  • 对活动变化的直接量化显示,没有显著的大规模重组.
  • 这些发现挑战了关于截肢后大脑可塑性的长期假设.

结论:

  • 截肢并不会在成年大脑中引起广泛的皮质重组.
  • 成年人的大脑保持稳定的神经表征,尽管失去四肢.
  • 这项研究提供了反对截肢后大规模皮质重组的关键证据.