使用基于DNA甲基化分类的IDH突变天体瘤预后的完善
Teresia Kling1, Sandra Ferreyra Vega1, Medha Suman1
1Sahlgrenska Center for Cancer Research, Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Brain pathology (Zurich, Switzerland)
|January 3, 2024
概括
基因组甲基化分析准确预测异酸脱酶 (IDH) 突变天体细胞瘤的结果,符合世界卫生组织 (WHO) 2021 年标准. 这种分子分类改进了预后,特别是对于高度质瘤.
科学领域:
- 神经瘤学神经瘤学
- 分子病理学分子病理学
- 基因组学就是基因组学.
背景情况:
- 2021年世界卫生组织 (WHO) 对异酸脱酶 (IDH) 突变天体细胞瘤的分级系统整合了组织学特征和CDKN2A/B同胞性删除状态.
- DNA甲基化分析对诊断中枢神经系统 (CNS) 瘤,包括质瘤越来越重要,并在全球临床实践中得到采用.
研究的目的:
- 评估基于DNA甲基化的成年类型IDH突变天体细胞瘤分类的预后价值.
- 为了比较甲基化概况的疗效与当前世卫组织2021年中枢神经系统患者预后标准.
主要方法:
- 对385个IDH突变天体细胞瘤的组织病理学诊断,全基因组DNA甲基化阵列数据和染色体拷贝数变化的分析.
- 使用世卫组织2021年中枢神经系统标准,染色体/基因变异和通过分子神经病理分类器进行DNA甲基化分类来评估预后.
主要成果:
- 基于DNA甲基化的分类证明了与WHO 2021年中枢神经系统标准对IDH突变星系细胞瘤的预后准确度相似.
- 甲基化分类确定了3级内的生存率较差,4级内的IDH突变天体细胞瘤的良好结果的患者.
结论:
- DNA甲基化分析为IDH突变天体细胞瘤提供了重要的预后信息.
- 基于甲基化的分类可以提高当前世卫组织2021年分级方案的精度,以改善患者管理.
相关概念视频
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...