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良性前列腺增生 - 一种具有潜在治疗后果的新型自身免疫性疾病?

Victoria Liedtke¹, Michael Stöckle², Kerstin Junker²

¹Faculty Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, 01968 Senftenberg, Germany.

Autoimmunity reviews

|January 3, 2024

概括

良性前列腺增生 (BPH) 可能涉及自身免疫反应,这表明它可以被归类为男性自身免疫疾病. 免疫抑制在减少BPH症状和炎症方面表现有前途.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
免疫学免疫学免疫学
病理生理学病理生理学

背景情况:

良性前列腺增生 (BPH) 是一种与年龄相关的疾病,原因不明,尽管慢性炎症也与之有关.
在前列腺炎症中,越来越多地发现了自身免疫反应,在自身免疫疾病患者中,BPH的患病率更高.

研究的目的:

探索自身免疫反应在BPH病理生理学中的潜在作用.
调查免疫抑制在管理BPH症状中的有效性.
为了识别BPH的潜在自身免疫标记物.

主要方法:

审查证据,将自身免疫性疾病和BPH联系起来.
分析TNF-α抑制剂对BPH症状和炎症的影响.
讨论新的诊断目标,如HEp-2细胞和线粒体DNA.

主要成果:

使用TNF-α抑制剂的免疫抑制可以减少同时患有自身免疫性疾病的患者的BPH症状和炎症.
在患有自身免疫性疾病的人群中观察到BPH患病率升高.
确定了BPH自身免疫反应的潜在诊断生物标志物.

结论:

自免疫反应很可能参与BPH的发病.
BPH可能代表男性的一种新型自身免疫性疾病.
针对自身免疫机制为BPH提供了一个新的治疗途径.

关键词:

反线粒体DNA抗体的抗体.这是一种自身免疫力.良性前列腺增生症良性前列腺增生症在LEDGF/p75中使用.

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