综合监测的关键需求:基于废水和临床流行病学在演变的场景中,从SARS-CoV-2中吸取教训
Annalaura Carducci1, Ileana Federigi2, Giulia Lauretani1
1Laboratory of Hygiene and Environmental Virology, Department of Biology, University of Pisa, Via S. Zeno 35/39, 56127, Pisa, Italy.
Food and environmental virology
|January 3, 2024
概括
污水监测和COVID-19的临床数据显示,在严格控制和分子测试期间存在显著的相关性. 调整数据以考虑变异性对于综合感染监测至关重要.
科学领域:
- 环境科学环境科学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 基于废水的流行病学 (WBE) 和临床监测是跟踪SARS-CoV-2的关键工具.
- 这两种方法都面临着影响数据解释的可变性挑战.
- 整合环境和临床数据需要解决这些变异性.
研究的目的:
- 分析污水中SARS-CoV-2度与报告的COVID-19病例之间的相关性.
- 评估各种因素对这种相关性的影响,包括WBE和临床数据调整.
- 为综合感染监测提供方法见解.
主要方法:
- 在原始污水和事件COVID-19病例 (2021-2023) 中SARS-CoV-2之间的相关性分析.
- 调整WBE数据以分析协议,污水流量和人口规模.
- 调整临床数据以适应人口结构.
- 评估下水道网络的差异和测试变化.
主要成果:
- 在限制性制 (ρ=0.50) 和独家分子测试 (ρ=0.49) 期间发现了显著的相关性.
- 在人口密集地区 (ρ=0.37) 和较短的下水道长度 (ρ=0.28) 中观察到微弱的正相关性.
- 确定了影响数据可靠性的关键因素.
结论:
- 数据调整和偏差评估对于综合环境和临床监测至关重要.
- 提出的方法方法可以帮助解释WBE和各种感染的临床数据.
- 强调WBE作为补充监控工具的实用性.
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