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Updated: Jul 6, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

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推断超分辨率组织架构通过整合空间转录学与组织学.

Daiwei Zhang1, Amelia Schroeder2, Hanying Yan2

  • 1Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Daiwei.Zhang@Pennmedicine.upenn.edu.

Nature biotechnology
|January 3, 2024
PubMed
概括

我们开发了iStar,这是一种结合空间转录学 (ST) 和组织学图像的新方法. iStar可以预测近乎单细胞分辨率的基因表达,即使仅仅是从组织学图像.

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相关概念视频

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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