患有2型糖尿病的亚洲多民族患者的功能轨迹,相关因素和结果
Liang Feng1, Yong Mong Bee2, Xiuju Fu3
1Program in Health Services & Systems Research, Duke-NUS Medical School, Singapore, Singapore.
新加坡2型糖尿病患者功能下降显示非线性模式. 渐进或快速估计的淋巴细胞过率 (eGFR) 降低显著增加末期病 (ESKD) 的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 在一个多民族的新加坡2型糖尿病人群中检查了估计的淋巴细胞过率 (eGFR) 轨迹,风险因素和末期病 (ESKD) 相关性.
- 2型糖尿病是全球慢性病和ESKD的主要原因,需要了解疾病的进展.
研究的目的:
- 分析2型糖尿病患者功能 (eGFR) 的非线性轨迹.
- 为了确定与不同的eGFR下降模式相关的因素.
- 为了确定与不同的eGFR轨迹相关的ESKD风险.
主要方法:
- 隐性类线性混合模型分析了62,080名多民族2型糖尿病患者 (2013-2019) 的eGFR轨迹.
- 多项逻辑回归确定了与eGFR轨迹相关的因素.
- 竞争的风险模型评估了eGFR轨迹与ESKD之间的关联.
主要成果:
- 确定了三个非线性eGFR轨迹类:稳定/渐进下降 (75%),渐进下降 (21.9%) 和快速下降 (3.1%).
- 渐进或快速的EGFR下降与年龄较小,女性性别,马来族裔,收入较低,吸烟,HbA1c较高,失脂症,不受控制的血压,白色素尿,心血管疾病和高血压有关.
- 与稳定下降相比,逐渐下降增加了6.14倍的ESKD危险;快速下降增加了82.55-倍.
结论:
- 在新加坡的多民族2型糖尿病患者中确定了三种不同的非线性功能轨迹.
- 大约25%的患者表现出渐进或快速的EGFR下降.
- eGFR轨迹与社会和可修改的风险因素相关,为ESKD风险预测提供信息.
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