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作为具有强大的抗瘤功效的选择性II型AXL抑制剂的1,6-纳菲西里丁衍生物的结构-活性关系研究

Linsheng Zhuo1, Mengqin Guo2, Siyi Zhang3

  • 1Postdoctoral Station for Basic Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.

European journal of medicinal chemistry
|January 3, 2024
PubMed
概括

研究人员开发了一种新型II型AXL抑制剂,化合物25c,显示出对MET激酶的高强度和选择性. 这种有前途的癌症治疗候选药物在临床前模型中有效抑制了瘤的生长和扩散.

关键词:
1,6-纳夫提里的使用情况这是一种AXL激酶抑制剂.激酶选择性的选择性基纳氨酸氨酸是什么

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