皮质灰色物质厚度和体积的变化及其与甲状腺功能过高患者的记忆功能的关联
Mukesh Kumar1,2, Sadhana Singh1,3, Shilpi Modi1
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Delhi, India.
Neuroendocrinology
|January 3, 2024
概括
甲状腺功能障碍与大脑结构变化有关. 这项研究发现甲状腺功能高的患者在特定的大脑区域的皮质厚度和体积增加,与甲状腺激素水平和记忆功能相关.
科学领域:
- 神经内分泌学神经内分泌学
- 神经成像是一种神经成像.
- 大脑结构 大脑结构
背景情况:
- 甲状腺功能过高是一种由甲状腺激素过多引起的内分泌疾病,会影响大脑功能.
- 神经成像技术的进步使得在甲状腺功能障碍症中对大脑变化的研究成为可能.
研究的目的:
- 为了检查区域皮质厚度和体积差异在甲状腺功能高的患者与对照.
- 为了将大脑的结构变化与甲状腺激素水平和认知功能相关联.
主要方法:
- 使用高分辨率MRI和FreeSurfer软件进行皮质分析.
- 对比34名甲状腺功能高患者和35名健康对照人群,控制年龄,性别,教育和内体积.
- 进行了临床/神经心理变量和大脑结构之间的相关性分析.
主要成果:
- 甲状腺功能过高的患者在上和前回旋中显著增加皮质厚度.
- 在几个大脑区域观察到皮层体积升高,包括右上和额头回旋.
- 甲状腺激素与特定区域的皮质厚度/体积正相关;记忆得分与皮质厚度负相关.
结论:
- 皮层的加厚和特定大脑区域的体积增加,为与甲状腺功能障碍相关的大脑损伤提供了洞察力.
- 这些发现突出了与甲状腺激素过量相关的结构性大脑变化.
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