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Updated: Jul 6, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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用GWAS总结统计数据从培训数据中获取的多基因风险评分方法的调整参数

Wei Jiang1, Ling Chen2, Matthew J Girgenti3

  • 1Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.

Nature communications
|January 3, 2024
PubMed
概括

PRStuning仅使用训练数据总结统计数据调整多基因风险评分 (PRS) 参数,增强疾病风险预测的隐私和准确性. 这种方法可以提高PRS的性能,而不需要外部个体级数据.

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