相关实验视频
Updated: Jul 6, 2025

03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
435
在胃癌中ECHS1的表达和临床意义
Ting Lu1, Liang Sun2, Qingmin Fan1
1Department of Ultrasound, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Journal of Cancer
|January 3, 2024
概括
短链伊诺伊尔-CoA水合酶 (ECHS1) 在胃癌 (GC) 中被上调,促进瘤生长和扩散. 高ECHS1表达与患者生存率差相关,这表明它是GC的潜在治疗标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 胃癌 (GC) 仍然是全球癌症死亡的主要原因,尽管治疗进展,但生存率低于最佳.
- 短链伊诺伊尔-CoA酸酶 (ECHS1) 在GC病变发生过程中的作用尚不清楚.
- 研究新的分子标对于改善GC患者的治疗结果至关重要.
研究的目的:
- 研究ECHS1在胃癌中的临床意义和生物学作用.
- 确定ECHS1表达与GC患者存活率和临床病理特征之间的关联.
- 探索ECHS1对GC细胞增殖和迁移的功能影响.
主要方法:
- 使用GEPIA和临床样本对GC组织和细胞系中ECHS1表达的分析.
- 评估ECHS1对GC细胞增殖和迁移的作用,通过殖民地形成和穿孔测试.
- 在ECHS1表达水平和患者生存结果 (OS,FP,PPS) 之间的相关性分析.
主要成果:
- 与正常组织相比,GC组织中的ECHS1mRNA和蛋白质水平明显上调.
- 增加ECHS1表达与晚期瘤入侵,淋巴结转移和更高的TNM阶段相关.
- 高ECHS1表达与较短的整体存活 (OS),首次进展 (FP) 和后进展存活 (PPS) 相关,特别是在特定的子组中.
- 在实验室中,ECHS1过度表达促进了GC细胞的增殖和迁移.
结论:
- 在胃癌中,ECHS1作为瘤基因起作用.
- ECHS1上调与瘤的攻击性行为和GC患者的不良预后有关.
- 在胃癌治疗中,ECHS1是一个有前途的治疗标.
相关概念视频
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Barrett Esophagus-II: Clinical Manifestations and Management
154
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
154
Barrett Esophagus-I: Introduction
98
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
98
Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K

