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改变肠道微生物群作为糖尿病冠状动脉疾病的潜在危险因素:一个双样本双向孟德尔随机化研究
Zhaopei Zeng1,2, Junxiong Qiu1,2, Yu Chen3
1Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
International journal of medical sciences
|January 3, 2024
概括
肠道细菌的不平衡,特别是Oxalobacter formigenes,与2型糖尿病和冠状动脉疾病有因果关系. 这种肠道微生物群的改变可能会增加糖尿病冠状动脉疾病的风险.
科学领域:
- 微生物组研究的研究.
- 代谢性疾病遗传学代谢性疾病遗传学
- 心血管流行病学心血管流行病学
背景情况:
- 肠道微生物群失调与2型糖尿病 (T2D) 和冠状动脉疾病 (CAD) 有关.
- 病因联系,特别是在糖尿病冠状动脉疾病 (DCAD) 中,仍然不清楚.
- 了解这些联系对于开发有针对性的干预措施至关重要.
研究的目的:
- 使用双向门德尔随机化研究肠道微生物群,T2D和CAD之间的因果关系.
- 为了确定特定的肠道细菌和代谢物,影响DCAD的发展.
- 阐明将肠道微生物群变化与DCAD风险联系起来的潜在机制.
主要方法:
- 双向门德尔随机化 (MR) 分析.
- 利用来自DIAGRAM,GERA,UKB,FHS和mibioGen队伍的大规模遗传数据.
- 检查了T2D,CAD,肠道微生物群和代谢物的全基因组关联研究 (GWAS).
主要成果:
- 发现Oxalobacter formigenes与T2D和CAD发病率的增加之间存在因果关系.
- 增加*Oxalobacteraceae*家族的存在与对T2D的遗传倾向有关 (β = 0.061).
- *杆菌*的存在与较高的CAD遗传可能性有关 (β = 0.082).
- 确定了CAD风险和*甲基细菌*,TMAO和卡尼丁之间的联系.
- 特定的代谢物 (proline,lysophosphatidylcholine,asparagine,salicylurate) 显示了与T2D和CAD的因果关系.
- 敏感性分析支持Oxalobacter formigenes作为DCAD的一个危险因素.
结论:
- *Oxalobacter formigenes* 在T2D和CAD中起因作用,可能调解DCAD风险.
- 肠道微生物群的变化代表了将T2D与CAD风险增加联系起来的重要途径.
- 需要对TMAO,卡尼丁和甲原体在CAD病因学的进一步研究.
- DCAD可能相互影响肠道微生物群组成.
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