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肺癌的进展会改变肺和肠道微生物组和脂质代谢

Mao Hagihara^1,2, Hideo Kato², Makoto Yamashita²

¹Department of Molecular Epidemiology and Biomedical Sciences, Aichi Medical University, Nagakute, 480-1195, Japan.

|January 3, 2024

概括

肺癌会改变肠道和肺部的微生物和脂质代谢. 这些多组变化揭示了肠肺轴机制,为肺癌治疗提供了潜在的新治疗点.

科学领域:

微生物学微生物学
代谢学代谢学代谢学
在瘤学瘤学.

背景情况:

肺癌仍然是癌症死亡的主要原因,尽管医学的进步.
了解肺癌发展的精确机制对于改善结果至关重要.

研究的目的:

研究肺和肠道微生物组变化与肺癌中宿主脂质代谢组变化之间的相关性.
为了确定潜在的肠肺轴机制和肺癌的治疗点.

主要方法:

在肺癌模型中对肺和肠道微生物组合的比较分析.
对宿主组织 (肺,血液,小肠,结肠) 的全面脂质代谢组分析.
多omics数据集成,以评估微生物组和代谢组变化之间的相关性.

主要成果:

肺癌诱导了肺 (减少了Firmicutes,Deferribacterota) 和肠道 (减少了Actinobacteria,Proteobacteria;增加了Cyanobacteria,Patescibacteria) 微生物群的显著变化.
在肺和肠道微生物之间激活视网醇,脂肪酸和亚麻酸代谢途径时观察到的逆相关性.
在脂质代谢物 (例如,肺部上腺,棕,牛脂,油酸的增加;血液/结肠的减少) 和前瘤分子 (Leukotriene B4,prostaglandin E2) 和抗瘤分子 (isohumulone,resolvin) 中发现了显著的变化.

结论:

微生物组和代谢组的变化与肺癌的发展有关.
这些多学科的发现凸显了肠肺轴在肺癌中的临床重要性.
已识别的机制和代谢物代表了肺癌治疗和预防的潜在新目标.

关键词:

肠肺轴肠肺轴肠肺轴脂质脂质是一种肺癌是一种肺癌.代谢组中的代谢.微生物组是一个微生物组.

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