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患有肥胖的青少年的甲状腺激素水平和BMI-SDS变化
Daniela Staníková1,2, Lea Krajčovičová1, Denisa Lobotková1
1Department of Pediatrics, Medical Faculty of Comenius University and National Institute for Children´s Diseases, Bratislava, Slovakia.
Frontiers in endocrinology
|January 3, 2024
概括
像TSH和FT4这样的甲状腺激素会影响肥胖青少年的体重变化. 较低的TSH和FT4基线水平与青少年女性的BMI-SDS降低有关,这表明在体重管理中发挥了作用.
科学领域:
- 内分泌学 在内分泌学.
- 儿童肥胖症 儿童肥胖症
- 代谢健康 代谢健康
背景情况:
- 甲状腺激素调节能量代谢,发热和基本代谢率.
- 自由甲状腺素 (FT4) 水平与食物偏好相关,可能会影响体重.
- 了解甲状腺激素的作用对于儿童群体的体重管理至关重要.
研究的目的:
- 调查基线甲状腺激素水平 (FT4,TSH) 与肥胖儿童和青少年体质指数标准偏差得分 (BMI-SDS) 变化之间的关系.
- 分析儿童患者与甲状腺功能相关的纵向体重变化.
主要方法:
- 一项纵向后续研究,涉及377名肥胖儿童和青少年,分组为青少年 (15-19岁) 和儿童 (10-14.9岁).
- 在基线测量甲状腺激素 (FT4,TSH);在基线和随访 (5.59 ± 1.85 个月) 评估的人类测量.
- 参与者按BMI-SDS变化 (下降与增加) 分类进行比较分析.
主要成果:
- 与BMI-SDS增加组相比,患有肥胖的青少年体验到BMI-SDS降低的TSH (2.4 vs. 3.2 mIU/l) 和FT4 (14.7 vs. 15.5 pmol/l) 的基线显著降低.
- 患有肥胖症和TSH低于平均值的青少年比例较高,BMI-SDS下降 (61.1%与38.6%相比).
- 患有肥胖和FT4低于中位数的青少年女性显示,BMI-SDS下降的百分比明显更高 (70.6%对23.5%).
结论:
- 在患有肥胖的青少年中,基线TSH和FT4水平升高与随访期间BMI-SDS增加有关.
- 这些发现表明,较高的FT4水平可能会导致肥胖患者的体重增加.
- 甲状腺激素水平可能在调节肥胖青少年的体重变化方面发挥作用.
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