连续静脉注射输液与普罗波对大鼠肠道代谢物的影响
Jiaying Li1, Zhongjie Zhang1, Hongyu Liu1
1Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China.
Biomedical reports
|January 3, 2024
概括
普罗波麻醉对老鼠肠道代谢物影响最小,随着时间的推移,在特定化合物如3基酸和酸中观察到一些轻微的变化. 这些变化没有显示出统计学意义,这表明对肠道平衡的影响有限.
科学领域:
- 胃肠病学 胃肠病学
- 麻醉学 麻醉学
- 微生物组研究 微生物组研究
背景情况:
- 微生物代谢物对肠道平衡和免疫功能至关重要.
- 普罗波是一种广泛使用的麻醉剂,但其对肠道代谢物的影响尚不清楚.
- 了解普罗波福的作用对于患者护理和管理潜在的副作用至关重要.
研究的目的:
- 为了研究连续静脉注射普罗波福尔输液对大鼠便代谢物的影响.
- 分析代谢物概况的变化,并识别受普罗波影响的特定化合物.
- 探索改变的代谢物和肠道微生物群之间的相关性.
主要方法:
- 八只老鼠接受了连续的静脉输血普罗福尔输液3小时.
- 在麻醉 (P) 之前和输液后的1,3,7天 (A1,A3,A7) 收集了便样本.
- 使用气体染色体-飞行时间质谱法 (GC-TOF-MS) 的非向代谢学被采用.
主要成果:
- 施用普罗波导致便代谢物类型和含量发生变化,尽管这些变化没有统计学意义.
- 3-基酸和棕酸水平从第3天到第7天增加,显示出显著的正相关性.
- 临酸在第3天下降,在第7天恢复到基线,其代谢途径在输液后7天被共同丰富.
结论:
- 连续静脉注射的普罗波对大鼠肠道代谢物具有统计学上微不足道的影响.
- 确定了特定的代谢物及其与肠道微生物的相关性,需要进一步调查.
- 这项研究提供了关于普罗波对肠道代谢的微妙影响的见解.
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